United Attends Pace And Responds With Half Length Win In Grade II, $200,000 San Marcos; Mandella & Prat Team For 1 ¼ Miles On Turf In 1:59.04ARCADIA, Calif. (Feb. 1, 2020)–Attentive to the pace today, Richard Mandella’s United was put into a drive midway around the far turn and he responded with a hard-fought three quarter length win in Saturday’s Grade II, $200,000 San Marcos Stakes at Santa Anita. Ridden by Flavien Prat, United, who cut back in distance off of a pair of second place finishes at a mile and one half on grass, got a mile and one quarter on turf in 1:59.04.“I think I made a mistake last time,” said Prat in reference to a second place finish as the even money favorite in the Grade II Hollywood Turf Cup at Del Mar Dec. 1. “I was trying to keep him covered up and it didn’t end up the way I wanted and I found myself too far back. Today, we broke off and we were in the race (early). He just (kept running) to the wire.”Second, beaten a head by eventual Horse of the Year Bricks and Mortar two starts back in the Grade I Breeders’ Cup Turf here Nov. 2, United was off as the 4-5 favorite in a field of six older horses and paid $3.60, $2.40 and $2.10.“You could see there wasn’t a lot of pace in the race,” said Mandella. “He’s got a big lumbering stride and you don’t want to get in the way of it. We just let him cruise along and that worked out well.”Owned by LNJ Foxwoods, United, a 5-year-old gelding by Giant’s Causeway out of the Pulling Punches mare Indy Punch, collected his first stakes win and improved his overall ledger to 12-4-3-1. With the winner’s check of $120,000, he went over the $1 million mark to $1,013,549.Ridden by Abel Cedillo, Cleopatra’s Strike put in a good run from off the pace to finish second by a neck in front of a fast finishing Oscar Dominguez. Off at 3-1, “Cleopatra” paid $3.20 and $2.20.Last around the far turn and extremely wide turning for home, Irish-bred Oscar Dominguez flew late to be third with Joel Rosario and paid $2.20 to show.Fractions on the race were 23.31, 46.92, 1:10.99 and 1:35.06.
FCPA Professor has been described as “the Wall Street Journal concerning all things FCPA-related,” and “the most authoritative source for those seeking to understand and apply the FCPA.”Set forth below are the topics discussed this week on FCPA Professor.In this FCPA Flash podcast episode, Daniel Suleiman (Covington & Burling who previously served as a senior official in the DOJ’s Criminal Division including as Deputy Chief of Staff & Counselor to the Assistant Attorney General) discusses the life cycle of FCPA internal investigations,This post highlights a recent speech in which Steven Peikin (Co-Director of the SEC’s Division of Enforcement) talked about the meanings of success of the SEC’s enforcement program as well as the remedies and relief available to the SEC in enforcement actions.This post offers a few observations about the United States – Mexico – Canada agreement compared to the FCPA specifically as it relates to “foreign official” issues and the express facilitation payments exception.As highlighted here, in a civil trial an L-3 executive testified that a representative agreement with a Qatar company “was cover for any kind of allegation that [L-3] has violated the FCPA.”This post rounds up other FCPA or related developments. How much do you know about the Foreign Corrupt Practices Act? Let’s find out in this week’s FCPA challenge.Elevate your FCPA knowledge and practical skills at the FCPA Institute – Philadelphia on October 18-19. Click here to learn more and register.
May 21 2018Stimulating the brain to alter its intrinsic reward system shows promise in the treatment of obesity, according to results presented in Barcelona at the European Society of Endocrinology annual meeting, ECE 2018. The technique has yielded positive results after just a single treatment session, revealing its potential to become a safer alternative to treat obesity, avoiding invasive surgery and drug side effects.Obesity is a global epidemic, with approximately 650 million adults and 340 million children and adolescents currently considered obese, and the disease contributing to an estimated 2.8 million deaths per year worldwide. It has been reported that, in some obesity cases, the reward system in the brain may be altered, causing a greater reward response to food than in normal weight individuals. This can make patients more vulnerable to craving, and can lead to weight gain. This dysfunction in the reward system can also be seen in cases of addiction to substances, e.g. drugs or alcohol, or behaviors, e.g. gambling.Deep Transcranial Magnetic Stimulation (dTMS) is a medical treatment that uses magnetic energy to stimulate neurons in specific areas of the brain. It is used to treat depression and addictive behaviors, and previous studies have suggested that dTMS could be a good option to reduce drug and food cravings. However, the potential mechanism driving these changes had not been investigated until now.In this study, Professor Livio Luzi and colleagues, from the Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, Italy, investigated the effects of dTMS on appetite and satiety in obese people. They studied the effects of a single 30 minute session of dTMS, at high or low frequency, on blood markers potentially associated with food reward in a group of 40 obese patients. They found that high frequency dTMS significantly increased blood levels of beta-endorphins – neurotransmitters involved in producing heightened feelings of reward after food ingestion – compared to low frequency dTMS or controls.Related StoriesDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustRush University Medical Center offers new FDA-approved treatment for brain aneurysmsResearch team to create new technology for tackling concussion”For the first time, this study is able to suggest an explanation of how dTMS could alter food cravings in obese subjects” says Professor Luzi. “We also found that some blood markers potentially associated with food reward, for example glucose, vary according to gender, suggesting male/female differences in how vulnerable patients are to food cravings, and their ability to lose weight.”Since the current study only measures changes in blood markers, the next steps for the research group include using brain imaging studies to directly identify how high frequency dTMS changes the structure and function of the obese brain, both short and long term, and extending this treatment to a larger population of obese patients.”Given the distressing effects of obesity in patients, and the socioeconomic burden of the condition, it is increasingly urgent to identify new strategies to counteract the current obesity trends. dTMS could present a much safer and cheaper alternative to treat obesity compared to drugs or surgery”, Professor Luzi adds. Source:https://www.ese-hormones.org/