President Donald Trump on Friday signed a two-bill spending package that fully funds the Pentagon in fiscal 2019, lifting defense officials from the challenge of coping with short-term spending measures for the first time in 10 years. The legislation’s enactment marks a rare achievement, especially after the president one week earlier signed a three-bill package funding the department’s military construction programs in FY 2019. The defense spending bill provides $674.4 billion in discretionary budget authority and represents a $17 billion increase in DOD’s base budget funding over the FY 2018 allocation. It fully funds the administration’s requested 16,400 end-strength increase this year, including boosting active forces by 15,600 personnel, reports Military Times. … While its long-term fate remains uncertain, an immigration program which has provided a significant source of financing for base redevelopment projects has been extended through Dec. 7. The EB-5 Immigrant Investor program grants 10,000 visas annually to foreigners and their families who have invested $1 million in projects in the United States that create at least 10 jobs, or who have invested $500,000 if the money supports areas of high unemployment. Numerous questions have been raised about the program, though, and lawmakers from both parties have proposed terminating it, reports CQ.DOD photo by Michael Strasser Dan Cohen AUTHOR
Email Facebook Changing West Eighth St. To “Jimi Hendrix Way” new-yorkers-want-call-w-8th-st-jimi-hendrix-way News New Yorkers Want To Call W. 8th St. “Jimi Hendrix Way” Twitter Greenwich Village, N.Y., home of Electric Lady Studios hopes the city will dub their neighborhood with the guitarist’s legendary namePhilip MerrillGRAMMYs Oct 5, 2017 – 4:29 pm The life and art of Jimi Hendrix are touchstones that artists and fans revisit, for example Outkast’s André 3000 playing him in the 2013 biopic Jimi: All Is By My Side. Now residents and merchants on W. 8th Street in New York City’s Greenwich Village hope co-naming their street “Jimi Hendrix Way” will have the same effect on tourists and foot traffic.Comparable to the 1977 renaming of a portion of W 106th Street as Duke Ellington Boulevard by the Riverside Drive home where he composed, these Greenwich Villagers want to memorialize the magic of Electric Lady Studios, which Hendrix bought in 1968 and opened in 1970, the year of his death.Local merchant Richard Geist said, “We want to bring that magic back.”The co-naming process is still at the stage of collecting petition signatures, after which the next steps are community board support followed by a full vote of the New York City Council.The Making Of Jimi Hendrix’s Are You Experienced?
WILMINGTON, MA — Here are highlights of the Wilmington Police Log for Sunday, June 30, 2019:Police were off with a group of juveniles at Town Hall. They check OK. Parents were aware. Kids were heading to CVS. (2:06am)Police reported 10 mailboxes damaged and/or on the ground on Lawrence Street. (2:11am)Police notified DPW of two street signs missing on New Hampshire Road. (2:46am)During a check of Town Hall, a resident notified police of a silver Mongoose bike that was on site for nearly month. Police notified DPW for pick-up. (8:58am)(DISCLAIMER: This information is public information. An arrest does not constitute a conviction. Any arrested person is innocent until proven guilty.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email email@example.com.Share this:TwitterFacebookLike this:Like Loading… RelatedPOLICE LOG for September 2: Beer Cans Found At Town Park; Spray Paint At Palmer Park; Sinkhole WorseningIn “Police Log”POLICE LOG for July 14: Unlocked Vehicles Entered Overnight; Trouble At Group Home; Street Sign & Mailbox VandalizedIn “Police Log”POLICE LOG for June 26: 2-Year-Old Locks Family Out; Co-Workers Get In Fight; Don’t Watch YouTube While DrivingIn “Police Log”
Reuters file [Representational Image]The benchmark BSE Sensex advanced over 100 points in early trade Wednesday on gains in bluechips like Maruti Suzuki, SBI, Tata Steel and ITC amid rising rupee and tumbling crude prices.Rising for the seventh straight session, the 30-share index spurted 104.05 points, or 0.29 per cent, to 36,451.13. The barometer had rallied over 1,387 points in the previous six sessions.Led by FMCG, oil and gas, PSU and realty, sectoral indices advanced up to 0.99 per cent. The NSE Nifty saw similar movement, rising up 36.60 points, or 0.34 per cent, to 10,945.30.Brokers said sustained buying by investors and foreign fund inflows, coupled with strengthening rupee against the US dollar and falling global crude oil prices, influenced trading sentiment here.Negative Asian cues on a likely Federal Reserve interest rate hike, limited the gains here, traders said. The rupee breached the 70 mark by surging 50 paise to trade at 69.94 against the dollar in early trade at the interbank forex market.Prominent gainers were Asian Paint, Axis Bank, ITC, Maruti Suzuki, SBI, HDFC, Yes Bank, Bharti Airtel, HUL, Tata Steel, Bajaj Auto, L&T, RIL and HDFC Bank, rising up to 1.70 per cent.However, Infosys emerged worst Sensex performer, falling 1.20 per cent, followed by Vedanta, TCS, Tata Motors and Sun Pharma. Shares of aviation companies rose after crude prices hit a 14-month low. InterGlobe Aviation, SpiceJet and Jet Airways rallied up to 5 per cent.Stocks of oil marketing companies like IOC, HPCL, BPCL and OIL too gained up to 1.43 per cent. Brent crude, an international benchmark, dropped 4.2 per cent lower to USD 57.07 per barrel Tuesday, a 14-month low.Meanwhile, foreign institutional investors (FIIs) bought shares to the tune of Rs 144.76 crore Tuesday, while domestic institutional investors (DIIs) sold shares worth a net of Rs 182.60, provisional data showed. Elsewhere in Asia, Japan’s Nikkei fell 0.43 per cent, Shanghai Composite Index shed 0.25 per cent, while Hong Kong’s Hang Seng rose 0.10 per cent.The US Dow Jones Industrial Average ended 0.35 per cent higher Tuesday.-PTI
Implementing the single-molecule DNA navigator. a) Schematic illustration of the PSEC system. An acyclic connected graph (i.e. a tree) is constructed on a rectangular DNA origami substrate of 100 x 70 nm^2. T1 and T2 are two types of fuels driving the PSEC on the tree. Initiator I was used to trigger the initiation of the PSEC from the entrance vertex ENT. b) propagation mechanism of the PSEC system. Initiator I recognizes and opens the T1ent hairpin at vertex ENT. The opened hairpin then captures and opens a T2 hairpin from the environment to start the cascade. c) A straight line paved by PSEC and visualized with DNA-PAINT. d) Four paved digits of “2017” imaged using atomic force microscopy (AFM). The T1 hairpins at the corner points were modified to prevent unwanted spans. The arrows indicate the direction of propagation. Credit: Nature Materials, doi: 10.1038/s41563-018-0205-3. © 2018 Science X Network Tying the knot: New DNA nanostructures , Science In the present study by Chao et al, the same basic principle of the HCR reaction scheme was used in a different computational context to develop a single-molecule DNA-navigator system. The platform explored all possible paths through a tree graph designed on an origami structure as a simply connected maze without cyclic paths. Such DNA origami structures are information-bearing nanostructures by nature with well-defined nanoscale geometry. The maze could be explored by proximal strand exchange cascade (PSEC) based on hybridization chain reactions. The researchers demonstrated that a system with a large number of single-molecule DNA navigators could collectively conduct parallel depth-first search (PDFS) on the tree to efficiently perform maze solving within 2-D origami. Initially the researchers conducted studies to test the PSEC design. Journal information: Nature Materials Citation: Solving mazes with single-molecule DNA navigators (2018, November 16) retrieved 18 August 2019 from https://phys.org/news/2018-11-mazes-single-molecule-dna.html More information: Jie Chao et al. Solving mazes with single-molecule DNA navigators, Nature Materials (2018). DOI: 10.1038/s41563-018-0205-3Renjun Pei et al. Training a molecular automaton to play a game, Nature Nanotechnology (2010). DOI: 10.1038/nnano.2010.194S. M. Douglas et al. A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads, Science (2012). DOI: 10.1126/science.1214081 Kinetics of the process were investigated at the single-molecule level in the study using time-resolved total internal reflection fluorescence microscopy (TIRF) in a setup with a prescribed starting point (P0) and five intermediate steps (P1-P5). Fluorescence in the setup was quenched using fluorescence resonance energy transfer (FRET), and the cascade was observed in real time by recording fluorescence signals continuously. The average speed of propagation was recorded to be 2.46 nm per minute, propagation across the straight line (54.4 nm) took approximately 22 minutes. The scientists then constructed the main model maze with 10 vertices that included an entrance vertex A and an exit vertex J, three junctions (B, D, E) an intermediate vertex (I) and four dead ends (C, F, G, H). Each path of the maze that was equivalent to a tree with 10 vertices was investigated using DNA investigators starting at root A. The PSEC reactions produced a mixture of various paths on the maze, confirmed with AFM. Each individual PSEC could progress on one of the five possible paths. Statistical analysis of the length distribution showed that the measured paths coincided well with the values predicted. To prevent the navigators from propagating through a wrong path with dead ends, the scientists designed a streptavidin-biotin tag-based method to selectively eliminate inaccurate path navigation. Only the correct path (PABDIJ) was followed in the maze therefore. The computational context used in the study allowed exploration of paths through tree graphs defined on the origami. The autonomous path explored by the DNA navigators proceeded unidirectionally and irreversibly, turning at junctions and corners on the origami platform as they were designed to. The design enabled parallel depth first search (PDFS) allowing each DNA navigator to individually explore any one of the paths through the given graph at a defined speed, greater than that previously achieved. The main advantage of the described biomolecular computer schemes in comparison to conventional electronic computing is they can be interfaced directly with biologically relevant processes. As a result, the scientists envision translational biomedical sensing and decision-making platforms with DNA origami and single-molecule diagnostics using decision trees. Future applications will also include simple sensors or those coupled to a molecular actuator to trigger downstream molecular cascades. , Nature Nanotechnology Pathfinding operations with DNA navigators make use of a localized strand exchange cascade process initiated at a unique trigger site on the origami platform. Automatic progression along paths is enabled by DNA hairpins containing a universal traversal sequence. By design, each single-molecule navigator can autonomously explore any of the possible paths through a 10-vertex rooted tree constructed in the study. The mazes were equivalent to a tree with an entrance at the root and an exit through one of the leaves. The study conducted by Jie Chao and co-workers resulted in exploring all paths taken by the DNA navigators to extract a specific solution path that connected a given pair of start and end vertices in the maze. As a result, the solution path was laid plainly on the origami platform and illustrated using single-molecule imaging. The approach is now published in Nature Materials, detailing the realization of molecular materials with embedded biomolecular computational functions to operate at the level of the single-molecule with potential to engineer intelligent nanorobots for future applications in industry and medicine.Sophisticated molecular tools were used in the past to create molecular machines that convert chemical, photonic or electric energy into rotary or linear movements at the nanoscale. For instance, Brownian motion at the nanoscale can be controllably converted into directed movements within DNA-based nanomachines using DNA hybridization reactions. Such DNA-based machines operate autonomously by following an embedded ‘molecular program’ pre-designed as a cascade reaction manually triggered via an external stimulus for each step of the operation. The focus of the field has progressively shifted to actualize DNA-based logic circuits using aptamers and DNAzymes to design molecular logic gates. For example, in 2006, Stojanovic and co-workers integrated more than 100 DNA logic gates to engineer an automation calledMAYA-II to play a game of Tic-Tac-Toe. Preceding studies demonstrated an enzyme free computing system based on hybridization chain reactions (HCR) to create logic-gates and logic circuits for more robust and efficient performance than the original systems. Single-molecule DNA navigators for maze-solving. a) Schematic illustration of magnetic bead-based selection. Exit vertex J is labelled with biotin to enable differentiation between the correct and wrong paths. Only if the PSEC reaches the correct exit J, would the biotin-modified T1exit-B strand be released. All wrong paths could be captured and removed by the Streptavidin-modified magmatic beads therefore. b) Details of the release of biotin modification at the exit J by the PSEC. c) AFM characterization of the correct solution after selection. The remaining structures all showed the correct solution path PABDIJ. d) Single-molecule and class-averaged DNA-PAINT characterization of the correct solution after selection. Credit: Nature Materials, doi: 10.1038/s41563-018-0205-3. Explore further The proximal strand exchange cascade (PSEC) system (working principle of the DNA navigator) was facilitated on a rectangular origami substrate made of three components, which included the physical implementation of a tree graph, full strands and an initiator strand. Vacant areas without staple extensions corresponded to walls in the maze, preventing propagation of the strand exchange cascade. The entrance and exit were defined and denoted as ENT and EXIT respectively. In the second component, two types of DNA hairpins, T1 and T2, were used as fuels to drive the PSEC on the tree graph. The two hairpins coexisted metastably in solution to hybridize and fuel the PSEC process with free energy . By design, information only propagated through the network in the presence of an initiator (Initiator I). Upon addition of initiator I, PSEC was conducted and observed using atomic force microscopy (AFM). To visualize an established formation, the scientists enabled DNA-navigator-based formation of the number 2017 as a proof-of-principle. Another technique known as DNA-PAINT was employed as a single-molecule, super-resolution imaging technique to reveal molecular features at the nanoscale to further substantiate the PSEC-based path paving process. The on-origami PSEC was highly specific, without intra- or inter-origami crosstalk. The field of intelligent nanorobotics is based on the great promise of molecular devices with information processing capabilities. In a new study that supports the trend of DNA-based information carriers, scientists have engineered a DNA navigator system that can perform single-molecule, parallel, depth-first search operations on a two-dimensional origami platform. Single-molecule characterization of PSEC kinetics. a) A straight line in the middle of the DNA origami was used as the test bed. Vertex P0 is the starting point and vertices P1-P5 are intermediate points. b) Details of the design of six parallel tests to measure the kinetics with time-resolved TIRF. T2 labelled with BHQ2 was used to quench T1 labelled with Cy3, assembling a kinetic profile at each step. The illustrated example shows the mechanism of quenching. c) Example TIRF images show the fluorescence changing with time across the six parallel tests from P0 to P5. d) Typical single-molecule fluorescence traces used to monitor quenching events occurring at vertices P0 to P5. e) Scatter plots showing statistical analysis of the length distribution per path. Credit: Nature Materials, doi: 10.1038/s41563-018-0205-3. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The PSEC-driven graph traversal on a maze. a) A maze design with 10 vertices. Arrows indicate the entrance vertex A and exit vertex J. b) The maze is equivalent to a rooted tree with 10 vertices. The entrance vertex A corresponds to the root of the tree. c) An AFM image showed the result of a transversal experiment generating all possible paths. In this DNA computing implementation of a PDFS algorithm, a vast number of PSEC events simultaneously occurred to realize the graph traversal on the maze. PSEC ending at the exit or deadends were highlighted in red circles. Invalid structures were highlighted with white circles. d) Typical paths found in the mixture seen from left to right. Only PABDIJ was the correct solution to the maze. e) Scatter plots showing the statistical analysis of the length distribution for each path. Credit: Nature Materials, doi: 10.1038/s41563-018-0205-3.
Just two days ago, Perfecto, a Perforce Software company introduced Perfecto Codeless, an AI-driven codeless testing solution for eliminating the need for coding skills in the dev testing process. Perfecto Codeless will help the development teams to automate the process of writing test scripts as it comes with machine learning (ML) capabilities. The scripts will be allowed to run continuously and fix themselves without disrupting operations. Eran Yaniv, Founder, and CEO at Perfecto wrote to us in an email, “Across our customer base, the number one cause of automation failure is scripting issues. This a huge barrier for achieving good test automation and teams making their way towards continuous testing. With the introduction of Perfecto Codeless, we are harnessing the power of machine learning to offer the next generation of codeless automation testing capabilities. By eliminating the need to write and maintain test scripts, teams save time and can focus on more complex tasks.” The development teams have the coding skills for writing Selenium or Appium scripts but it is better if their time is spent on product development and innovation. Perfecto Codeless comes with tools that help the teams to quickly generate quality test scripts and maintain them. Features of Perfecto Codeless Smart capabilities to maintain scripts Perfecto’s ML capabilities address object maintenance issues within the code. If there is a need for deleting, moving or changing the code, Perfecto Codeless makes it happen agnostically without delaying the process. Interconnected components All the components of the testing process are connected right from creation to execution and analysis. Codeless automation in the cloud Perfecto Codeless provides codeless test automation in the cloud that allows teams to manage the pace and demands that come with test automation. Perfecto Codeless also provides the flexibility, performance, and scalability needed to ensure quality throughout the SDLC. Eran Kinsbruner, Chief Evangelist at Perfecto wrote to us in an email, “In recent years, codeless test automation has become a top priority for testers, as well as the developers that aim to expedite their test creation and maximize testing reliability. These professionals are looking at codeless as a preferred solution to embed into their testing responsibilities. Perfecto Codeless will take DevOps to the next level, relieving testers and developers of the time-intensive responsibility of coding and giving them time back to focus on product development and innovation to help accelerate the software delivery lifecycle (SDLC) for their business.” Read Next Rachel Batish’s 3 tips to build your own interactive conversational app DeepMind researchers provide theoretical analysis on recommender system, ‘echo chamber’ and ‘filter bubble effect’ Waymo to sell its 3D perimeter LIDAR sensors to companies outside of self-driving
Posted by Share WestJet launches nonstop YYC-Nashville, brings back Halifax-Gander route Tags: Calgary, Halifax, Nashville, New Routes, WestJet Travelweek Group CALGARY — WestJet has announced brand new nonstop service between Calgary and Nashville and the reintroduction of its Halifax-Gander route as part of its busy summer schedule.Service between Calgary International Airport (YYC) and Nashville International Airport (BNA) begins on May 4 and runs twice weekly. With the launch, WestJet will become the first Canadian carrier to offer nonstop service between the two destinations.The airline began service to Nashville from Toronto last year and currently flies six times weekly on WestJet Encore. Flights from Calgary to Nashville will be operated on Boeing 737 aircraft.“WestJet continues to boost our flight network out of our Calgary hub,” said Brian Znotins, WestJet Vice-President Network Planning, Alliances and Corporate Development. “Just as the route out of Toronto has been embraced, we expect that Western Canadians will be thrilled to have the only nonstop access from Calgary to one of the most popular and happening cities in the U.S.”More news: Onex paying big to get WestJet and that will send airfares soaring, says CWTAs part of its 2017 summer schedule, which was announced on the same day as the new Nashville route, the airline also revealed it will once again fly its route from Halifax to Gander, Newfoundland. The year-round service starts daily on April 30, with one-way fares starting at $164.59.“A convenient afternoon departure will provide travellers access to Halifax and connections to WestJet’s robust network beyond, without the early morning rise,” said Reg Wright, President and CEO, Gander International Airport Authority. “Passengers have clearly told us they wanted more afternoon departures, so this is welcome news for Central Newfoundland residents.”WestJet’s 2017 summer schedule also includes new nonstop additional flights from Toronto to Orlando, Los Angeles, Las Vegas, Montreal and Moncton, as well as four new weekly flights between Vancouver and Hamilton and the addition of a daily flight to San Francisco. Service from Calgary will increase with six additional weekly flights to Toronto, and a once-daily flight to both Winnipeg and Regina will be added. Service from Edmonton to Kelowna will increase by 12 weekly flights and by one additional weekly flight to Las Vegas, while service from Kelowna to Winnipeg will increase by one weekly flight for a total of four times weekly. Lastly, existing winter service has been extended through the summer, including six daily flights between Vancouver and Kelowna, and five daily flights from Vancouver to Prince George.More news: Consolidation in the cruise industry as PONANT set to acquire Paul Gauguin CruisesFor more information go to westjet.com. Tuesday, January 31, 2017 << Previous PostNext Post >>
Travelweek Group Tuesday, October 24, 2017 << Previous PostNext Post >> Share Posted by Tags: Fairmont Hotels & Resorts, Hawaii, Promotions, Wellness Travel WAILEA, HAWAII — In keeping with Hawaii’s long-standing tradition of maintaining mindfulness and wellness, Fairmont Kea Lani has unveiled a new wellness package that promotes healthy living and inner balance.Called ‘inspire Your Energy Wellness Package’, it includes daily breakfast buffet at Kea Lani Restaurant, daily fitness classes like barre, meditation and pilates, a 30-minute consultation with a fitness & wellness coordinator, and two 60-minute body treatments at the award-winning willow Stream Spa.The package also includes daily access to Willow Stream Spa’s heat and hydro facilities, and a signed copy of Eric Saperston’s book ‘Live in Wonder: Quests, quotes and Questions To Jumpstart Your Journey’.Package rates start at US$789 per night, double occupancy, in a Fairmont Suite.“The Inspire Your Energy Wellness Package is designed for guests interested in living a healthy, uplifted and energized life,” says Shannah Milstead, director of sales and marketing of the 450-key all suite and villa resort. “We’ve combined restorative treatments and mindfulness with an opportunity for guests to recharge and transform into a better version of themselves,” explains Milstead. “The Inspire Your Energy Wellness Package allows guests to approach wellness in a very personalized way with the guidance and expertise of our Energy Ambassador.”Launched in 2016, the Fairmont Kea Lani’s Inspire Your Energy program provides an integrated style to wellness by connecting guests to the activities they are passionate about while enjoying the tropical outdoor surroundings of Wailea, distinct mana (power or energy) of the islands and unique culture of Hawai’i.Fairmont Kea Lani, is Hawaii’s only all-suite and villa luxury resort. Nestled on the golden sands of Wailea’s Polo Beach, this award-winning oceanfront property is renowned for its distinct approach to beach resort luxury. Be well, live well with Fairmont Kea Lani’s new wellness package
D.R. announces new safety measures including more F&B inspection By: The Associated Press SANTO DOMINGO — The D.R. has announced new safety measures that include stricter controls on food and beverage inspections in resort areas.The D.R.’s Minister of Tourism, Francisco Javier Garcia, announced the new measures yesterday. The destination is working to allay concerns in the wake of the high-profile deaths of more than half a dozen U.S. tourists.According to reports, D.R. properties will have to “provide inspectors with detailed food handling protocols as well as comprehensive information on all food and beverage suppliers.”When guests check in, front desk staff will review emergency procedures, plus an emergency centre is being established in Bavaro in Punta Cana. There will also be closer monitoring of the medical services provided by resorts including the qualifications of doctors, nurses and other medical team members.The D.R. has seen its visitor numbers drop in the wake of the publicity surrounding the tourist deaths. In June, Garcia said the deaths were not part of a mysterious wave of fatalities but a medically and statistically normal phenomenon that has been lumped together by the U.S. media. << Previous PostNext Post >> Tags: Dominican Republic, Minister of Tourism Friday, July 19, 2019 Share